Amoxicillin

Did you mean co-amoxiclav?

A beta-lactam penicillin antibiotic. Ampicillin and amoxicillin have equivalent activity (i.e. organisms that are sensitive to ampicillin are sensitive to amoxicillin). Ampicillin is no longer used at this Trust.

Bactericidal.
Has some Gram negative activity.
Reasonable oral absorption (oral preparation amoxicillin).
Usual adult dose IV amoxicillin 500mg-1g TDS (higher doses: 2g 4 hourly, are used for treatment of endocarditis), PO Amoxicillin 500mg-1g TDS.
Reduce dose in moderate to severe renal impairment.
Moderate risk of Clostridium difficile infection.

Main indications
Upper respiratory tract infection e.g. otitis media, sinusitis
Alternative for UTI if known sensitive organism
Exacerbation of COPD
Low to moderate severity community acquired pneumonia
Mild/moderate severity hospital acquired pneumonia

Active against most strains of:
Streptococcus pneumoniae
Beta haemolytic streptococci
Enterococcus faecalis
Listeria monocytogenes

Not active against most strains of:
Staphylococcus aureus; coagulase negative staphylococci
Atypical pneumonia causing pathogens (e.g. legionella, chlamydia, mycoplasma)
Anaerobes from GI tract e.g. Bacteroides fragilis
Pseudomonas
Klebsiella spp.
Enterococcus faecium

Variable activity against Escherichia coli more than 50% strains are resistant